Dr. Jeff Tarrasch joined Hospital Medicine in the Department of Medicine as an Instructor in July 2026. He grew up in Los Altos, CA before attending University of California, Los Angeles where he studied chemistry. He developed an interest in research throughout college, and upon graduating he moved to Ann Arbor, MI where he began work in a structural biology lab. He missed public service, however, and switched careers to work as a high school teacher in Chicago. Throughout his time working in a lab and as a high school educator, Dr. Tarrasch solidified his interests in research, education, and public service. He took these interests to St. Louis where he attended medical school at WashU Medicine. While in medical school he continued working with high school students through university programs and led science classes at KIPP charter school. He earned his medical degree in 2023 and began internal medicine residency at WashU Medicine/Barnes-Jewish Hospita in 2026.
Education
- BS, Chemistry: University of California, Los Angeles, CA (2014)
- MA, Secondary Education: Dominican University, San Rafael, CA (2018)
- MD: Washington University School of Medicine, St. Louis, MO (2023)
- Residency, Internal Medicine: Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, MO (2026)
Clinical Interests
Hospital medicine, inpatient care, infectious diseases, medical student and resident education, preventative care, and quality improvement
Publications
Jeffrey Tarrasch, Amanda K. Verma, Jonathan D. Moreno. “SCAD Gone Bad. A Rare Case of SCAD Requiring Cardiac Transplantation” JACC: Case Reports, In Press
Tarrasch J, England P, Hurst VT, O’Keefe R, Cipriano C. “Patients with metastatic disease are at highest risk for anxiety and depression in an orthopedic oncology patient population” JCO Oncology, 1407-1416 (2022)
Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK. “Structural insights into the activation of metabotropic glutamate receptors.” Nature 566.7742 (2019)
Zhang, Yan, Bingfa Sun, Dan Feng, Hongli Hu, Matthew Chu, Qianhui Qu, Jeffrey T. Tarrasch,
Shane Li, Tong Sun Kobilka, Brian K. Kobilka, and Georgios Skiniotis. “Cryo-EM Structure of the Activated GLP-1 Receptor in Complex with a G Protein.” Nature 546.7657 (2017)
Su, Min, Emily Z. Guo, Xinqiang Ding, Yan Li, Jeffrey T. Tarrasch, Charles L. Brooks, Zhaohui Xu, and Georgios Skiniotis. “Mechanism of Vps4 Hexamer Function Revealed by Cryo-EM.” Science Advances (2017)
Liang, Yi-Lynn, Maryam Khoshouei, Mazdak Radjainia, Yan Zhang, Alisa Glukhova, Jeffrey Tarrasch, David M. Thal, Sebastian G. B. Furness, George Christopoulos, Thomas Coudrat, Radostin Danev, Wolfgang Baumeister, Laurence J. Miller, Arthur Christopoulos, Brian K. Kobilka, Denise Wootten, Georgios Skiniotis, and Patrick M. Sexton. “Phase-plate Cryo-EM Structure of a Class B GPCRG-protein Complex.” Nature (2017)
Cahill, Thomas J., Alex R. B. Thomsen, Jeffrey T. Tarrasch, Bianca Plouffe, Anthony H. Nguyen,
Fan Yang, Li-Yin Huang, Alem W. Kahsai, Daniel L. Bassoni, Bryant J. Gavino, Jane E. Lamerdin,
Sarah Triest, Arun K. Shukla, Benjamin Berger, John Little, Albert Antar, Adi Blanc, Chang-Xiu Qu, Xin Chen, Kouki Kawakami, Asuka Inoue, Junken Aoki, Jan Steyaert, Jin-Peng Sun, Michel Bouvier, Georgios Skiniotis, and Robert J. Lefkowitz. “Distinct Conformations of GPCR B-arrestin Complexes Mediate Desensitization, Signaling, and Endocytosis.” Proceedings of the National Academy of Sciences 114.10 (2017)
Gu S, Sachleben JR, Boughter CT, Nawrocka WI, Borowska MT, Tarrasch JT, Skiniotis G, Roux B,
Adams EJ. Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on Vγ9Vδ2 T cell activation. Proc Natl Acad Sci U S A. 2017 Aug 29 ;114(35):E7311- E7320. doi: 10.1073/pnas.1707547114. Epub 2017 Aug 14. PMID: 28807997; PMCID:PMC5584448.
Thomsen, Alex R.b., Bianca Plouffe, Thomas J. Cahill, Arun K. Shukla, Jeffrey T. Tarrasch, Annie M. Dosey, Alem W. Kahsai, Ryan T. Strachan, Biswaranjan Pani, Jacob P. Mahoney, Liyin Huang, Billy Breton, Franziska M. Heydenreich, Roger K. Sunahara, Georgios Skiniotis, Michel Bouvier, and Robert J. Lefkowitz. “GPCR-G Protein-B-Arrestin Super-Complex Mediates Sustained G Protein Signaling.” Cell 166.4 (2016): 907-19
Brown, W. Clay, David L. Akey, Jamie R. Konwerski, Jeffrey T. Tarrasch, Georgios Skiniotis,
Richard J. Kuhn, and Janet L. Smith. “Extended Surface for Membrane Association in Zika Virus NS1 Structure.” Nature Structural & Molecular Biology 23.9 (2016)
Hussain, Hazrat, Yang Du, Nicola J. Scull, Jonas S. Mortensen, Jeffrey Tarrasch, Hyoung Eun
Bae, Claus J. Loland, Bernadette Byrne, Brian K. Kobilka, and Pil Seok Chae. “Accessible
Mannitol- Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation.”
Chemistry – A European Journal 22.21 (2016)
Ehsan, Muhammad, Yang Du, Nicola J. Scull, Elena Tikhonova, Jeffrey Tarrasch, Jonas S.
Mortensen, Claus J. Loland, Georgios Skiniotis, Lan Guan, Bernadette Byrne, Brian K. Kobilka, and Pil Seok Chae. “Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies.” Journal of the American Chemical Society 138.11 (2016)
Drake, Eric J., Bradley R. Miller, Ce Shi, Jeffrey T. Tarrasch, Jesse A. Sundlov, C. Leigh Allen,
Georgios Skiniotis, Courtney C. Aldrich, and Andrew M. Gulick. “Structures of Two Distinct Conformations of Holo-non-ribosomal Peptide Synthetases.” Nature 529.7585 (2016)
Oral Presentations
Tarrasch J, Zajarias A, Lasala J, Brescia A, Kachroo P, Roberts H, Quader N, Kaneko T, Sintek M.
(2024, March 30). Non-coronary isolation deployment technique with balloon expandable
transcatheter heart valves lowers pacemaker implantation rates. American College of Cardiology, Atlanta, Georgia.
Poster Presentations
Justin Vincent, Jeffrey Tarrasch, Harrison Lancaster, Elena Deych, Michael Rich, Douglas Mann. (2025, May 30). Validation of SGLT2i Efficacy in Geriatric Patients with Heart Failure. Mentors in Medicine, St. Louis, Missouri
Tarrasch J, Zajarias A, Lasala J, Brescia A, Kachroo P, Roberts H, Quader N, Kaneko T, Sintek M.
(2024, May 30). Non-coronary isolation deployment technique with balloon expandable
transcatheter heart valves lowers pacemaker implantation rates. Mentors in Medicine, St. Louis, Missouri